Vitamin K beyond Coagulation: a Role in Bone Health and Disease
نویسندگان
چکیده
Vitamin K has long been associated solely with its role in haemostasis. The last two decades brought new intriguing insights to the function of vitamin K. While the present recommendations for daily intake are based mainly on amounts required to maintain coagulation, they may not be high enough to ensure adequate functions of vitamin K not involved in blood clotting, In the present review the role of vitamin K on bone in health and disease is being discussed. Theoretical grounds connected with the function and diagnostic application of the vitamin K-dependent protein osteocalcin is described. Available clinical data related to the use of vitamin K in the prevention and treatment of osteoporosis is provided.
منابع مشابه
A case report of temporary and acquired vitamin K-dependent clotting factor deficiency without any response to administrated vitamin K
Abstract Background and Objectives Vitamin K-dependent clotting factor deficiency (VKCFD) is usually an acquired problem due to liver disease, malabsorption, and overdose of warfarin. In the present paper the significance and role of vitamin K-dependent coagulation factors in menorrhagia were evaluated. Case We present a rare case of 43 year woman with acquired vitamin K deficiency and se...
متن کاملEffects of Vitamins K in Neonates and Young Infants
Vitamin K is required for the hepatic production of blood coagulation factors II, VII, IX and X. The term vitamin K refers to a variety of fat-soluble 2-methyl-1, 4-naphthoquinone derivatives. Vitamin K1 (phylloquinone) occurs in green plants, while vitamin K2 (menaquinone) is synthesized by microbial in the gut. The recommended dose of vitamin K in neonates is 1 mg intramuscularly. For infants...
متن کاملPleiotropic actions of vitamin K: protector of bone health and beyond?
Vitamin K is a nutrient that was originally identified as an essential factor for blood coagulation. Recently, vitamin K has emerged as a potential protector against osteoporosis, atherosclerosis, and hepatocarcinoma. Accumulated evidence indicates that subclinical non-hemostatic vitamin K deficiency in extrahepatic tissues, particularly in bone and possibly in vasculature, exists widely in the...
متن کاملReview Article The role of menaquinones (vitamin K2) in human health
Recent reports have attributed the potential health benefits of vitamin K beyond its function to activate hepatic coagulation factors. Moreover, several studies have suggested that menaquinones, also known as vitamin K2, may be more effective in activating extra-hepatic vitamin K-dependent proteins than phylloquinone, also known as vitamin K1. Nevertheless, present dietary reference values (DRV...
متن کاملVitamin K: an old vitamin in a new perspective
The topic of "Vitamin K" is currently booming on the health products market. Vitamin K is known to be important for blood coagulation. Current research increasingly indicates that the antihaemorrhagic vitamin has a considerable benefit in the prevention and treatment of bone and vascular disease. Vitamin K1 (phylloquinone) is more abundant in foods but less bioactive than the vitamin K2 menaqui...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011